AT-1001
Product Specifications
CAS Number
1314801-63-2
Target
AChR|||Others
Related Pathways
Neuroscience|||Others
Bioactivity
AT-1001 is an ?3?4 nAChR partial agonist. AT-1001 attenuates stress-induced reinstatement of nicotine seeking in a rat model of relapse and induces minimal withdrawal in dependent rats. AT-1001 also potently and reversibly blocks epibatidine-induced inward currents in HEK cells transfected with ?3?4 nAChR. Importantly, AT-1001 potently and dose-dependently blocks nicotine self-administration in rats, without affecting food responding. When tested in a nucleus accumbens (NAcs) synaptosomal preparation, AT-1001 inhibits nicotine-induced [³H]dopamine release poorly and at significantly higher concentrations compared with mecamylamine and conotoxin MII.
Smiles
N([C@H]1C[C@@]2(N(C)[C@](C1)(CCC2)[H])[H])C3=C(Br)C=CC=C3
Molecular Formula
C15H21BrN2
Molecular Weight
309.24
Shipping Conditions
Cool pack
Storage Temperature
-20°C
Available Sizes
Curated Selection
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