ELND006
Product Specifications
CAS Number
1333990-84-3
Target
Others, Beta Amyloid, Gamma-secretase
Related Pathways
Proteases/Proteasome, Stem Cells, Others, Neuroscience
Bioactivity
ELND006 is a novel gamma secretase inhibitor previously under investigation for the oral treatment of Alzheimer's disease. ELND006 shows poor solubility and has moderate to high permeability. The in vivo performance of the ELND006 nanosuspension was tested in fed and fasted beagle dogs and compared with a gelatin capsule containing reference API. The results show that nanosizing ELND006 profoundly improved the oral bioavailability and virtually eliminated variation resulting from food intake.
Smiles
S(=O)(=O)(N1[C@@H](C=2C(C=3C1=CC(F)=C(F)C3)=NNC2)C4CC4)C5=CC=C(C(F)(F)F)C=C5
Molecular Formula
C20H14F5N3O2S
Molecular Weight
455.4
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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