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Carotegrast methyl HCl

Product Specifications

CAS Number

1338380-52-1

Target

Integrin, Others

Related Pathways

Others, Cytoskeletal Signaling

Bioactivity

Carotegrast methyl, also known as AJM300 and PTC-100, is an orally-active small molecule that antagonises the α4 integrin receptor. AJM300 reduces inflammation by blocking leucocyte trafficking. Oral treatment with AJM300 dose-dependently inhibited lymphocyte homing to Peyer's patches and increased the peripheral lymphocyte count in the same dose range. AJM300 dose-dependently prevented the development of experimental colitis in mice.

Smiles

Cl.COC(=O)[C@H](Cc1ccc(cc1)-n1c(=O)n(C)c2ccc(cc2c1=O)N(C)C)NC(=O)c1c(Cl)cccc1Cl

Molecular Formula

C25H20Cl3N3O5

Molecular Weight

548.801

Shipping Conditions

Ice Packs

Storage Temperature

-20°C

Available Sizes

Frequently Asked Questions

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