AM-8508
Product Specifications
CAS Number
1338483-67-2
Target
Others
Related Pathways
Others
Bioactivity
AM-8508 is a potent and selective PI3Kδ inhibitor. AM-8508 showed good cellular potency (in vitro pAKT IC50 = 4.6 nM) . AM-8505 xhibited excellent HWB potency (HWB (pAKT) IC50 = 2.7 nM) . AM-8508 inhibit KLH-specific antibodies in animal models, signifying its potential for the treatment of human inflammatory diseases. PI3Kα and PI3Kβ are ubiquitously expressed and play a role in cell growth, division, and survival.
Smiles
[C@H](NC=1C(C#N)=C(N)N=CN1)(C)C=2N(C=3C(N2)=CC=C(F)C3)C=4C=CC=NC4
Molecular Formula
C19H15FN8
Molecular Weight
374.37
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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