CLR01 sodium

CLR01 is a molecular tweezer. CLR01 reduces aggregated, pathologic, and seeding-competent α-synuclein in experimental multiple system atrophy. CLR01 inhibits aberrant superoxide dismutase 1 (SOD1) self-assembly in vitro and in the G93A-SOD1 mouse model of ALS. CLR01 inhibits Ebola and Zika virus infection. CLR01 Stabilizes a Disordered Protein-Protein Interface. CLR01, Modulates Aggregation of the Mutant p53 DNA Binding Domain and Inhibits Its Toxicity.

[Na+].[Na+].[H][C@]12C[C@]([H])(c3ccccc13)c1cc3c(cc21)[C@]1([H])C[C@@]3([H])c2c1c(OP(O)([O-])=O)c1c(c2OP(O)([O-])=O)[C@@]2([H])C[C@]1([H])c1cc3c(cc21)[C@@]1([H])C[C@]3([H])c2ccccc12