Naldemedine tosylate
Product Specifications
CAS Number
1345728-04-2
Target
Opioid Receptor|||Others
Related Pathways
Others|||Endocrinology/Hormones|||GPCR/G Protein|||Neuroscience
Bioactivity
Naldemedine tosylate (S-297995) is an orally active ?-opioid receptor antagonist (PAMORA) with high binding affinities (K_i = 0.34, 0.43, 0.94 nM) and potent antagonist activities (IC_50 = 25.57, 7.09, 16.1 nM) towards human recombinant ?-, ?-, and ?-opioid receptors, respectively. It is utilized in research on opioid-induced constipation (OIC) and is anticipated to interact with the 3CL proenzyme encoded by the SARS-CoV-2 genome.
Smiles
S(=O)(=O)(O)C1=CC=C(C)C=C1.O[C@]12[C@@]34C=5C(O[C@]3(C(O)=C(C(NC(C)(C)C6=NC(=NO6)C7=CC=CC=C7)=O)C1)[H])=C(O)C=CC5C[C@]2(N(CC8CC8)CC4)[H]
Molecular Formula
C39H42N4O9S
Molecular Weight
742.84
Shipping Conditions
Cool pack
Storage Temperature
-20°C
Available Sizes
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