KRH102053
Product Specifications
CAS Number
1353254-53-1
Target
Others
Related Pathways
Others
Bioactivity
KRH102053 is a HIF-1alpha inhibitor. KRH102053 decreased the protein level of HIF-1alpha and the mRNA levels of HIF-regulated downstream target genes, such as vascular endothelial growth factor, aldolase A, enolase 1 and monocarboxylate transporter 4. Consistent with these results, KRH102053 also inhibited the rates of HIF-related migration and invasion of HOS cells as well as the degree of tube formation in human umbilical vein endothelium cells.
Smiles
O(C)C1C=2C(OC(C)(C)C1OC(C(CCSC)N)=O)=CC=C(NCC3=CC=C(OC)C=C3)C2
Molecular Formula
C25H34N2O5S
Molecular Weight
474.61
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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