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PT-S58

Product Specifications

CAS Number

1356497-92-1

Target

Others|||PPAR

Related Pathways

Metabolism|||Others|||DNA Damage/DNA Repair

Bioactivity

PT-S58 is a PPAR ?/? full antagonist, and a derivative of GSK0660. PT-S58 has a three-fold higher affinity for the receptor than GSK0660 and is a potent inhibitor of agonist-induced target gene expression. PT-S58 are effective on PPRE-independent functions of PPAR?/?. Unlike GSK0660, PT-S58 blocks the recruitment co-repressor molecules such as SMRT.

Smiles

S(NC1=C(OC)C=C(NC(C)(C)C)C=C1)(=O)(=O)C2=C(C(OC)=O)SC=C2

Molecular Formula

C17H22N2O5S2

Molecular Weight

398.5

Shipping Conditions

Cool pack

Storage Temperature

-20°C

Available Sizes

Curated Selection

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