M3541
Product Specifications
CAS Number
1360628-91-6
Target
Apoptosis, ATM/ATR
Related Pathways
PI3K/Akt/mTOR signaling, Apoptosis, DNA Damage/DNA Repair
Purity
0.9947
Bioactivity
M3541 is a selectively potent and orally active ATM inhibitor with potential antitumor activity.M-3541 inhibits ATM kinase activity and ATM-mediated signaling by binding to ATM.M3541 prevents activation of DNA damage checkpoints, inhibits DNA damage repair, contributes to apoptosis, and induces death of ATM overexpressing tumor cells.
Smiles
O=C1N(C=2C=3C(=CC(OC)=C(C3)C4=CN(C)N=C4)N=CC2N1C)C5=C(F)C=C(C#N)C=C5
Molecular Formula
C23H17FN6O2
Molecular Weight
428.42
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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