HM90822
Product Specifications
CAS Number
1363145-46-3
Target
Apoptosis|||IAP
Related Pathways
Apoptosis
Purity
0.9966
Bioactivity
HM90822 is a novel synthetic apoptotic protein (IAP) antagonist that induces apoptosis in human pancreatic cancer cells through proteasome-dependent degradation of IAPs containing the BIR2/3 structural domain.HM90822 inhibits the expression of XIAP and cIAP1/2 proteins in HM822-sensitive Panc-1 and BxPC-3 cells, induces ubiquitylation of IAPs and promotes induces IAP ubiquitination and promotes proteasome-dependent IAP degradation.
Smiles
N(C=1C2=C(C=C(OC)C(NC(=O)[C@H]3N(C([C@@H](NC([C@@H](NC)C)=O)[C@](C)(C)C)=O)CCC3)=C2)N=CN1)C4=C(F)C(Cl)=C(F)C=C4
Molecular Formula
C30H36ClF2N7O4
Molecular Weight
632.1
Shipping Conditions
Cool pack
Storage Temperature
-20°C
Available Sizes
Curated Selection
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