BE-16627B
Product Specifications
CAS Number
137530-61-1
Target
Others
Related Pathways
Others
Bioactivity
BE-16627B is a novel metalloproteinase (MP) inhibitor isolated from Streptomyces sp. BE16627B selectively inhibited MPs such as human stromelysin and 92 kD gelatinase. After the cells were cultured with BE16627B for 5 days, BE16627B inhibited MP activity in the primary culture supernatants from synovial cells in a dose-dependent fashion without showing apparent cytotoxicity or affecting the production and secretion of MPs. Its IC50 for active collagenolysis before activation by trypsin was 25 microM.
Smiles
C(C(N[C@H](C(N[C@@H]([C@@H](C)C)C(O)=O)=O)CO)=O)(CC(NO)=O)CC(C)C
Molecular Formula
C16H29N3O7
Molecular Weight
375.42
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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