Lanabecestat HCl
Product Specifications
CAS Number
1383986-31-9
Target
Others, Beta-Secretase
Related Pathways
Neuroscience, Others
Bioactivity
Lanabecestat, also known as AZD3293 and LY3314814, is a potent, highly permeable, orally active, blood-brain barrier (BBB) penetrating, BACE1 inhibitor with unique slow off-rate kinetics. AZD3293 displayed significant dose- and time-dependent reductions in plasma, cerebrospinal fluid, and brain concentrations of Aβ40, Aβ42, and sAβPPβ.
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Cl.CO[C@H]1CC[C@@]2(Cc3ccc(cc3[C@@]22N=C(C)C(N)=N2)-c2cncc(c2)C#CC)CC1
Molecular Formula
C26H29ClN4O
Molecular Weight
448.995
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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