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MRT-92 HCl salt

Product Specifications

CAS Number

1428307-52-1

Target

Others

Related Pathways

Others

Bioactivity

MRT-92 is a potent and selective Smoothened (Smo) receptor inhibitor. MRT-92 displays subnanomolar antagonist activity against Smo in various Hh cell-based assays. MRT-92 inhibits rodent cerebellar granule cell proliferation induced by Hh pathway activation through pharmacologic (half maximal inhibitory concentration [IC50] = 0.4 nM) or genetic manipulation. Smo is the target of anticancer drugs that bind to a long and narrow cavity in the 7-transmembrane (7TM) domain.

Smiles

Cl.COc1cc(cc(OC)c1OC)C(=O)NC(=N)Nc1ccc(C)c(NC(=O)c2ccc(CCc3ccccc3)cc2)c1

Molecular Formula

C33H35ClN4O5

Molecular Weight

603.12

Shipping Conditions

Ice Packs

Storage Temperature

-20°C

Available Sizes

Frequently Asked Questions

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