HJC-0123
Product Specifications
CAS Number
1430420-02-2
Target
Apoptosis, STAT, Others, Interleukin, TGF-beta/Smad
Related Pathways
JAK/STAT signaling, Apoptosis, Immunology/Inflammation, Others, Stem Cells
Bioactivity
Downregulate phosphorylation of STAT3, increase the expression of cleaved caspase-3, inhibit cell cycle progression and promote apoptosis in breast and pancreatic cancer cells with low micromolar to nanomolar IC50 values. Furthermore, HJC-0123 significantly suppressed estrogen receptor (ER) -negative breast cancer MDA-MB-231 xenograft tumor growth in vivo (p.o.), indicating its great potential as an efficacious and orally bioavailable drug candidate for human cancer therapy.
Smiles
C(NC=1C=C2C(=CC1)C=CS2(=O)=O)(=O)C=3C4=C(N=C(C3)C5=CC=CC=C5)C=CC=C4
Molecular Formula
C24H16N2O3S
Molecular Weight
412.46
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
MBS7171441 Inquire
Rabbit anti-Escherichia coli (strain SE11) leuS Polyclonal Antibody
Sign In for Pricing
View Details 
E11168m 96 Tests
ELISA Kit For Receptor-interacting serine/threonine-protein kinase 3
Sign In for Pricing
View Details orb2645301 1 g
2-phenyl-1- (trifluoromethyl) -4- (4- (trifluoromethyl) phenyl) -1H-imidazole
Sign In for Pricing
View Details 
LV781870 1.0 µg DNA
RPS2P46 Lentiviral Vector (Human) (EF1a) (pLenti-GIII-EF1a)
Sign In for Pricing
View Details