GNE-431
Product Specifications
CAS Number
1433820-83-7
Target
Others, BTK
Related Pathways
Angiogenesis, Tyrosine Kinase/Adaptors, Others
Bioactivity
GNE-431 is a potent, selective and noncovalent Btk inhibitor with IC50 of 3.2 nM. GNE-431 showed excellent potency against the C481R, T474I, and T474M mutants. GNE-431 may provide a treatment option to patients, especially those who have acquired resistance to ibrutinib by mutation of Cys481 or Thr474.
Smiles
O=C1C=2N(C3=C(C2)CCCC3)CCN1C4=C(CO)C(=CC=N4)C=5C=C(NC=6C=C7N(N6)CCN(C)C7)C=8N(N5)C=CN8
Molecular Formula
C30H32N10O2
Molecular Weight
564.64
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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