Ciprokiren
Product Specifications
CAS Number
143631-62-3
Target
Others, RAAS
Related Pathways
Endocrinology/Hormones, Others
Bioactivity
Ciprokiren is a renin inhibitor discovered by Roche. Ciprokinen inhibited human renin in a buffer and human plasma with an IC50 of 0.07 and 0.65 nmol/L, respectively. In animal models, acute and chronic administration of ciprokinen lead to a reduction in arterial blood pressure. Development of ciprokinen was discontinued at a preclinical stage.
Smiles
[C@@H](CC1=CN=CN1)(NC([C@H](CC2=CC=CC=C2)CS(C(C(=O)N3CCOCC3)(C)C)(=O)=O)=O)C(N[C@@H](CC4CCCCC4)[C@H]([C@@H](O)C5CC5)O)=O
Molecular Formula
C37H55N5O8S
Molecular Weight
729.93
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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