Cmpd-A
Product Specifications
CAS Number
1446399-26-3
Target
Others
Related Pathways
Others
Bioactivity
Cmpd-A is a time-dependent CENP-E inhibitor with potent antitumor activity. Cmpd-A inhibits the ATPase activity of the CENP-E motor domain, acting as a time-dependent inhibitor with an ATP-competitive-like behavior. Cmpd-A causes chromosome misalignment on the metaphase plate, leading to prolonged mitotic arrest. Treatment with Cmpd-A induces antiproliferation in multiple cancer cell lines.
Smiles
C(N(CCN(C)C)C1C=2C(S(=O)(=O)C1)=C(C#N)C(C(F)(F)F)=CC2)(=O)C3=C(N4C(=N3)C=CC=C4OC)C5=CC(C)=C(F)C=C5
Molecular Formula
C30H27F4N5O4S
Molecular Weight
629.63
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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