ACT-672125
Product Specifications
CAS Number
1449367-94-5
Target
Others, CXCR
Related Pathways
Autophagy, Immunology/Inflammation, GPCR/G Protein, Others
Bioactivity
ACT-672125 is a Potent CXCR3 Antagonist with Therapeutic Potential in Autoimmune Diseases. ACT-672125 showed good physicochemical properties and safety profile. In a proof-of-mechanism model of lung inflammation, ACT-672125 inhibited the recruitment of CXCR3 expressing T cells into the inflamed lung in a dose-dependent manner.
Smiles
C(F)(F)(F)C1=NC(=C(S1)N2C[C@@H](C)N(C(CN3C(C)=NC(C)=N3)=O)CC2)C=4NC=5C(N4)=CC=C(C5)C6=NOC(C)=N6
Molecular Formula
C25H25F3N10O2S
Molecular Weight
586.59
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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