Scytonemin
Product Specifications
CAS Number
152075-98-4
Target
Others, Apoptosis, Reactive Oxygen Species, PLK
Related Pathways
Immunology/Inflammation, Apoptosis, Metabolism, Cell Cycle/Checkpoint, Others, NF-κB
Bioactivity
Scytonemin is a biological pigment synthesized by many strains of cyanobacteria, including Calothrix sp., Lyngbya aestuarii, and others. Scytonemin is also a potent PKL1 inhibitor, which inhibits cell proliferation and arrests cell cycle through downregulating Plk1 activity in many cancel cells. Scytonemin was able to inhibit the proliferation of three myeloma cells in a dose-dependent manner, while U266 was the most sensitive one to scytonemin. Scytonemin , representing a novel Plk1 inhibitor, induced the inhibition of cell growth and cell cycle arrest in multiple myeloma cells by specifically decreasing Plk1 activity.
Smiles
O=C1C(=C2C(C1=CC3=CC=C(O)C=C3)=NC=4C2=CC=CC4)C5=C6C(C(=CC7=CC=C(O)C=C7)C5=O)=NC=8C6=CC=CC8
Molecular Formula
C36H20N2O4
Molecular Weight
544.55
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
Frequently Asked Questions
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