MK-8666
Product Specifications
CAS Number
1544739-76-5
Target
Endogenous Metabolite, Others
Related Pathways
Metabolism, Others
Bioactivity
MK-8666 is a partial GPCR (G-protein-coupled receptor) agonist that is coordinated with the action of GPR40. GPR40, also known as free fatty acid (FFA) receptor 1 modulates fatty acid-induced insulin secretion in pancreatic beta cells and in intestinal enteroendocrine cells. Thus, MK-8666 has been investigated for treatment of type 2 diabetes mellitus and has been shown to robustly lower glucose without negative effects.
Smiles
C(O)(=O)[C@H]1[C@]2([C@@]1(CC=3C2=CN=C(OCC4=CC(=CC=C4)C5=C(C)C=C(OCCCS(C)(=O)=O)C=C5C)C3)[H])[H]
Molecular Formula
C29H31NO6S
Molecular Weight
521.62
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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