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VUF14480

Product Specifications

CAS Number

1605304-31-1

Target

Others

Related Pathways

Others

Bioactivity

VUF14480 is a covalent partial agonist that interacts with cysteine 98 (3.36) of the human histamine H? receptor. VUF14480 was shown to be a partial agonist of hH4 receptor-mediated G protein signalling and ?-arrestin2 recruitment. VUF14480 bound covalently to the hH? receptor with submicromolar affinity. Serine substitution of C98 (3.36) prevented this covalent interaction.

Smiles

C(=C)C=1N=C(C=C(N1)C2=CC=CC=C2)N3CCN(C)CC3

Molecular Formula

C17H20N4

Molecular Weight

280.37

Shipping Conditions

Cool pack

Storage Temperature

-20°C

Available Sizes

Curated Selection

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