VUF14480
Product Specifications
CAS Number
1605304-31-1
Target
Others
Related Pathways
Others
Bioactivity
VUF14480 is a covalent partial agonist that interacts with cysteine 98 (3.36) of the human histamine H? receptor. VUF14480 was shown to be a partial agonist of hH4 receptor-mediated G protein signalling and ?-arrestin2 recruitment. VUF14480 bound covalently to the hH? receptor with submicromolar affinity. Serine substitution of C98 (3.36) prevented this covalent interaction.
Smiles
C(=C)C=1N=C(C=C(N1)C2=CC=CC=C2)N3CCN(C)CC3
Molecular Formula
C17H20N4
Molecular Weight
280.37
Shipping Conditions
Cool pack
Storage Temperature
-20°C
Available Sizes
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