Deucravacitinib HCl
Product Specifications
CAS Number
1609392-28-0
Target
JAK, Interleukin, IFNAR
Related Pathways
JAK/STAT signaling, Stem Cells, Immunology/Inflammation, Angiogenesis, Tyrosine Kinase/Adaptors, Chromatin/Epigenetic
Bioactivity
Deucravacitinib HCl is a Highly Potent and Selective Allosteric Inhibitor of TYK2. BMS-986165 Blocks Il-12, IL-23 and type I Interferon Signaling and Provides for Robust Efficacy in Preclinical Models of Inflammatory Bowel Disease. MS-986165 potently binds to the Tyk2 pseudokinase domain (Ki = 0.02 nM), and is highly selective against a panel of 265 kinases and pseudokinases. The compound potently inhibited IL-23-, IL-12-, and Type I interferon-driven cellular signaling and transcriptional responses (IC50 range 2-14 nM) .
Smiles
Cl.[2H]C([2H])([2H])NC(=O)c1nnc(NC(=O)C2CC2)cc1Nc1cccc(-c2ncn(C)n2)c1OC
Molecular Formula
C20H20D3ClN8O3
Molecular Weight
461.93
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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