What is the catalog number for AMG151 HCl?

The catalog number for AMG151 HCl is T70391.

What sizes are available for AMG151 HCl?

AMG151 HCl is available in the following size(s): 25 mg, 50 mg, 100 mg.

How many pack sizes does AMG151 HCl come in?

AMG151 HCl is available in 3 different pack sizes.

Is AMG151 HCl in stock?

AMG151 HCl is currently made to order / not held in immediate stock. Contact us for lead time.

Who manufactures AMG151 HCl?

AMG151 HCl is manufactured by Molfinity.

What is the estimated delivery time for AMG151 HCl?

Estimated delivery time for AMG151 HCl is approximately 10 business day(s), depending on your location.

AMG151 HCl

Product Specifications

CAS Number

1609674-80-7

Target

Others

Related Pathways

Others

Bioactivity

ARRY-403, also known as AMG-151, is an orally available allosteric glucokinase (GK) activator developed for the treatment of type 2 diabetes mellitus (T2DM) . ARRY-403 has many favorable physicochemical characteristics and ADME properties (low potential to cause drug–drug interactions (DDIs) . ARRY-403 potently activates human glucokinase (GK) in vitro (EC50 = 79 nM at 5 mM glucose), with an S0.5 = 0.93 mM glucose (ARRY-403 at 5 mM) and Vmax = 134% compared to the no activator control. It possesses good in vitro drug-like properties (aqueous solubility, cell permeability, low low potential for drug-drug interactions, low predicted hepatic clearance), and selectivity against broad panels of receptors and enzymes.