BAY 61-3606 HCl
Product Specifications
CAS Number
1615197-10-8
Target
Others, Apoptosis, Syk
Related Pathways
Angiogenesis, Apoptosis, Others, Tyrosine Kinase/Adaptors
Bioactivity
BAY 61-3606 HCl is a cell-permeable, reversible inhibitor of spleen tyrosine kinase. BAY 61-3606 HCl can inhibit degranulation and block cytokine release from mast cells. Oral administration of BAY 61-3606 to rats was shown to suppress antigen-induced passive cutaneous anaphylactic reaction, bronchoconstriction, and bronchial edema. It can also sensitize MCF-7 breast cancer cells to TNF-related apoptosis-inducing ligand (TRAIL) -mediated apoptosis by inhibiting Cdk9. This compound has been used in a pre-clinical model to explore the feasibility of targeting Syk in the treatment of retinoblastoma.
Smiles
Cl.COc1ccc(cc1OC)-c1cc2nccn2c(Nc2ncccc2C(N)=O)n1
Molecular Formula
C20H19ClN6O3
Molecular Weight
426.86
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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