CHF-6366
Product Specifications
CAS Number
1615208-41-7
Target
Others, AChR, Calcium Channel, Adrenergic Receptor
Related Pathways
GPCR/G Protein, Metabolism, Neuroscience, Others, Membrane transporter/Ion channel
Bioactivity
CHF-6366 is a dual-action chemical compound acting as a potent M3 muscarinic antagonist and β2-adrenergic receptors agonist, with respective pK i values of 10.4 and 11.4. Additionally, it exhibits weak calcium channel inhibitory properties (IC 50 ~50 μM) and demonstrates the ability to inhibit bronchoconstriction in guinea pigs, making it a viable candidate for chronic obstructive pulmonary disease (COPD) research.
Smiles
[C@@H](CNCCCCOC(=O)C=1C=C(COC2=CC([C@@H](NC(O[C@@H]3C4CCN(C3)CC4)=O)C5=CC=CC=C5)=CC=C2)N(C)N1)(O)C6=C7C(=C(O)C=C6)NC(=O)C=C7
Molecular Formula
C42H48N6O8
Molecular Weight
764.87
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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