SF0166
Product Specifications
CAS Number
1621332-91-9
Target
Others|||Integrin
Related Pathways
Cytoskeletal Signaling|||Others
Bioactivity
SF0166 is a potent, selective antagonist of ? v ? 3, demonstrating IC 50 values of 0.6 nM for ? v ? 3, 8 nM for ? v ? 6, and 13 nM for ? v ? 8. It effectively inhibits cellular adhesion to vitronectin in human, rat, rabbit, and dog cell lines, with IC 50 values ranging from 7.6 pM to 76 nM. Additionally, SF0166 significantly reduces neovascularization in the oxygen-induced retinopathy mouse model.
Smiles
[C@@H](CC(O)=O)(N1C(=O)N(CCCC=2NC=3C(=CC2)CCCN3)CC1)C=4C=CC(OC(F)F)=NC4
Molecular Formula
C23H27F2N5O4
Molecular Weight
475.49
Shipping Conditions
Cool pack
Storage Temperature
-20°C
Available Sizes
Curated Selection
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