TOP1362
Product Specifications
CAS Number
1630203-25-6
Target
Others
Related Pathways
Others
Bioactivity
TOP1362 is a Narrow Spectrum Kinase Inhibitors Demonstrate Promise for the Treatment of Dry Eye Disease and Other Ocular Inflammatory Disorders. TOP1362 strongly inhibited the kinase targets p38α, Syk, Src, and Lck, blocked the rise in p38α expression in hyperosmolar Chang cells, and potently reduced inflammatory cytokine release in cellular models of innate and adaptive immunities. In the EIU model, TOP1362 dose-dependently attenuated the LPS-induced rise in inflammatory cell infiltration and ocular cytokine levels with efficacy comparable to that of dexamethasone.
Smiles
O(C=1C2=C(C(NC(NC3=C(OC)C(NS(C)(=O)=O)=CC(C(C)(C)C)=C3)=O)=CC1)C=CC=C2)C=4C=C(NC5=CC(C(NCCCN6CCOCC6)=O)=CC(OC)=C5)N=CC4
Molecular Formula
C43H51N7O8S
Molecular Weight
825.97
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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