CI-898 HCl
Product Specifications
CAS Number
1658520-97-8
Target
Parasite, DHFR, Others, Antifolate, DNA/RNA Synthesis, Antibiotic, Antibacterial
Related Pathways
Cell Cycle/Checkpoint, Microbiology/Virology, Metabolism, Others, DNA Damage/DNA Repair
Bioactivity
CI-898 HCl is a lipophilic antifolate inhibitor of dihydrofolate reductase (DHFR) . It has enhanced binding to DHFR in the presence of the cofactor NADPH. Cl-898 HCl inhibits cell growth and halts the cell cycle at the G1/S phase in L1210 mouse lymphocytic leukemia cells and is active against methotrexate-resistant cancer cell lines. It also enhances the activity of doxorubicin, cyclophosphamide, and 6-thioguanine (6-TG) in mice with advanced stage P338 leukemia.
Smiles
Cl.Cl.Cl.COc1cc(NCc2ccc3nc(N)nc(N)c3c2C)cc(OC)c1OC
Molecular Formula
C19H26Cl3N5O3
Molecular Weight
478.8
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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