PAT-347
Product Specifications
CAS Number
1689554-51-5
Target
Others, PDE
Related Pathways
Metabolism, Others
Bioactivity
PAT-347 is a potent Autotaxin Inhibitor. Autotaxin (ATX) is a secreted enzyme responsible for the hydrolysis of lysophosphatidylcholine (LPC) to the bioactive lysophosphatidic acid (LPA) and choline. The ATX-LPA signaling pathway is implicated in cell survival, migration, and proliferation; thus, the inhibition of ATX is a recognized therapeutic target for a number of diseases including fibrotic diseases, cancer, and inflammation, among others.
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C(CN1C=2C(C(SC3=C(F)C(C(O)=O)=CC=C3)=C1C)=CC=C(Cl)C2F)(=O)N4CC5(C=6C4=CC=CC6)CC5
Molecular Formula
C28H21ClF2N2O3S
Molecular Weight
538.99
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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