APTO-253 HCl
Product Specifications
CAS Number
1691221-67-6
Target
Others, c-Myc
Related Pathways
Others, Cell Cycle/Checkpoint
Bioactivity
APTO-253, also known as LOR-253, LT-253, is a small molecule inhibitor of human metal-regulatory transcription factor 1 (MTF-1) with potential antitumor activity. MTF-1 inhibitor LOR-253 inhibits MTF-1 activity and thereby induces the expression of MTF-1 dependent tumor suppressor factor Kruppel like factor 4 (KLF4) . This subsequently leads to the downregulation of cyclin D1, blocking cell cycle progression and proliferation. This agent also causes decreased expression of genes involved in tumor hypoxia and angiogenesis.
Smiles
Cl.Cc1[nH]c2ccc(F)cc2c1-c1nc2c([nH]1)c1cccnc1c1ncccc21
Molecular Formula
C22H15ClFN5
Molecular Weight
403.84
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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