What is the catalog number for APTO-253 HCl?

The catalog number for APTO-253 HCl is T70273.

What sizes are available for APTO-253 HCl?

APTO-253 HCl is available in the following size(s): 25 mg, 50 mg, 100 mg.

How many pack sizes does APTO-253 HCl come in?

APTO-253 HCl is available in 3 different pack sizes.

Is APTO-253 HCl in stock?

APTO-253 HCl is currently made to order / not held in immediate stock. Contact us for lead time.

Who manufactures APTO-253 HCl?

APTO-253 HCl is manufactured by Molfinity.

What is the estimated delivery time for APTO-253 HCl?

Estimated delivery time for APTO-253 HCl is approximately 10 business day(s), depending on your location.

APTO-253 HCl

Product Specifications

CAS Number

1691221-67-6

Target

Others, c-Myc

Related Pathways

Others, Cell Cycle/Checkpoint

Bioactivity

APTO-253, also known as LOR-253, LT-253, is a small molecule inhibitor of human metal-regulatory transcription factor 1 (MTF-1) with potential antitumor activity. MTF-1 inhibitor LOR-253 inhibits MTF-1 activity and thereby induces the expression of MTF-1 dependent tumor suppressor factor Kruppel like factor 4 (KLF4) . This subsequently leads to the downregulation of cyclin D1, blocking cell cycle progression and proliferation. This agent also causes decreased expression of genes involved in tumor hypoxia and angiogenesis.