3A-MPLA

Monophosphoryl lipid A (MPLA) is a natural agonist for the toll-like receptor-4 (TLR4) . It is useful as an adjuvant in immunization. MPLA is a safe prophylactic agent and has immunotherapeutic applications. It induces tumor necrosis factor and interleukin (IL) -1β, however not as efficient as lipopolysaccharide (LPS) . MPLA improves immune response during bacterial sepsis infection.

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