ADL 08-0011 HCl
Product Specifications
CAS Number
170098-43-8
Target
Others, Opioid Receptor
Related Pathways
Others, Neuroscience, GPCR/G Protein, Endocrinology/Hormones
Bioactivity
ADL 08-0011 is an active metabolite of the μ-opioid receptor antagonist alvimopan. It is produced from alvimopan via amide hydrolysis by gut microbiota. ADL 08-0011 is a μ-opioid receptor antagonist (Ki = 0.25 nM) . It is selective for μ-opioid receptors over κ- and δ-opioid receptors (Kis = 15.8 and 31.6 nM, respectively) . ADL 08-0011 inhibits endomorphin 1-induced inhibition of electrically induced contraction of isolated guinea pig ileum (pA2 = 9.4) . In vivo, ADL 08-0011 (0.03-1 mg/kg) reverses loperamide-induced delayed gastric emptying in a rat model of castor oil-induced diarrhea.
Smiles
Cl.C[C@H]1CN(C[C@H](Cc2ccccc2)C(O)=O)CC[C@@]1(C)c1cccc(O)c1
Molecular Formula
C23H30ClNO3
Molecular Weight
403.947
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
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