LFS-829
Product Specifications
CAS Number
1799330-89-4
Target
Others
Related Pathways
Others
Bioactivity
LFS-829 is a a small-molecule antagonist of exportin-1. LFS-829 showed low-range nanomolar activities. Oral administration of LFS-829 can significantly reverse the pathological features of colitis model mice. LFS-829 can attenuate dual NF-κB signaling and the Nrf2 cytoprotection pathway via targeting exportin-1 in colitis mice. Moreover, LFS-829 has a very low risk of cardiotoxicity and acute toxicity. LFS-829 holds great promise for the treatment of colitis and may warrant translation for use in clinical trials.
Smiles
S(C=CCCN=C=S)(=O)C1=CC(C(F)(F)F)=CC(C(F)(F)F)=C1
Molecular Formula
C13H9F6NOS2
Molecular Weight
373.34
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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