Milvexian TFA
Product Specifications
CAS Number
1802426-00-1
Target
Others|||Factor Xa
Related Pathways
Metabolism|||Others
Bioactivity
Milvexian, also known as BMS-986177 and JNJ-70033093, is a blood coagulation factor XIa inhibitor. Milvexian demonstrated good selectivity over plasma kallikrein?Ki = 44 nM (400-fold selective), and chymotrypsin?Ki = 35 nM (318-fold selective) . At a dose of 1.5 mg/kg, Milvexian exhibited an overall exposure of 1215 nM/h, low clearance of 10.3 mL/min/kg, and oral bioavailability of 32%.
Smiles
OC(=O)C(F)(F)F.C[C@@H]1CCC[C@@H](c2cc(ccn2)-c2c(NC1=O)cnn2C(F)F)n1cnc(cc1=O)-c1cc(Cl)ccc1-n1cc(Cl)nn1
Molecular Formula
C30H26Cl2F5N9O4
Molecular Weight
742.49
Shipping Conditions
Cool pack
Storage Temperature
-20°C
Available Sizes
Curated Selection
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