Tomivosertib HCl
Product Specifications
CAS Number
1849590-02-8
Target
Others, MNK, PD-1/PD-L1
Related Pathways
Apoptosis, Cell Cycle/Checkpoint, Immunology/Inflammation, Others, MAPK
Bioactivity
Tomivosertib, also known as eFT508 is a MNK1/2 inhibitor. Tomivosertib binds to and inhibits the activity of MNK1 and 2. This prevents MNK1/2-mediated signaling, and inhibits the phosphorylation of certain regulatory proteins, including eukaryotic translation initiation factor 4E (eIF4E), that regulate the translation of messenger RNAs (mRNAs) involved in tumor cell proliferation, angiogenesis, survival and immune signaling.
Smiles
Cl.Cc1cc(Nc2cc(N)ncn2)c(=O)n2c1C(=O)NC21CCCCC1
Molecular Formula
C17H21ClN6O2
Molecular Weight
376.845
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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