PF-06463922 acetate
Product Specifications
CAS Number
1924207-18-0
Target
Apoptosis, ROS Kinase, ALK, Others
Related Pathways
Tyrosine Kinase/Adaptors, Angiogenesis, Others, Apoptosis
Bioactivity
PF-06463922 acetate is a potent, selective brain-penetrable inhibitor of both anaplastic lymphoma kinase (ALK) and c-ros Oncogene 1 (ROS1) with strong activity against all known ALK and ROS1 mutants identified in patients with crizotinib-resistant disease. PF-06463922 is in clinical trials for the treatment of non–small cell lung cancer (NSCLC) .
Smiles
CC(O)=O.C[C@H]1Oc2cc(cnc2N)-c2c(CN(C)C(=O)c3ccc(F)cc13)nn(C)c2C#N
Molecular Formula
C23H23FN6O4
Molecular Weight
466.46
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
Frequently Asked Questions
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