NCI-006
Product Specifications
CAS Number
1964516-64-0
Target
ROS, Others, Apoptosis, Dehydrogenase
Related Pathways
Apoptosis, Immunology/Inflammation, Metabolism, Others
Bioactivity
NCI-006 is a potent new inhibitor of lactate dehydrogenase (LDH) that disrupts tumor growth in mice. LDH inhibition slows tumor growth but rapidly redirects pyruvate to support mitochondrial metabolism. Inhibiting both mitochondrial complex 1 and LDH suppresses metabolic plasticity of glycolytic tumors in vivo, significantly prolonging tumor growth inhibition.
Smiles
C(C1=C(CC2CC2)N(N=C1C3=CC(C#CC=4SC(C)=CC4)=C(F)C=C3)C5=NC(C(O)=O)=CS5)C6=CC(F)=C(S(N)(=O)=O)C=C6
Molecular Formula
C31H24F2N4O4S3
Molecular Weight
650.74
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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