Brostallicin HCl
Product Specifications
CAS Number
203258-38-2
Target
DNA Alkylator/Crosslinker, Others
Related Pathways
Others, DNA Damage/DNA Repair
Bioactivity
Brostallicin is a synthetic, alpha-bromoacrylic, second-generation minor groove binder (MGB), related to distamycin A, with potential antineoplastic activity. Brostallicin binds to DNA minor groove DNA, after having formed a highly reactive glutathione (GSH) -brostallicin complex in the presence of the enzyme glutathione S-transferase (GST), which is overexpressed in cancer cells; DNA replication and cell division are inhibited, resulting in tumor cell death. Compared to typical MGBs, this agent appears to bind covalently to DNA in a different manner and its activity does not depend on a functional DNA mismatch repair (MMR) mechanism. Accordingly, brostallicin may be effective against MMR-defective tumors that are refractory to various anticancer agents.
Smiles
Cl.Cn1cc(NC(=O)c2cc(NC(=O)c3cc(NC(=O)c4cc(NC(=O)C(Br)=C)cn4C)cn3C)cn2C)cc1C(=O)NCCNC(N)=N
Molecular Formula
C30H36BrClN12O5
Molecular Weight
760.04
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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