What is the catalog number for Brostallicin HCl?

The catalog number for Brostallicin HCl is T69978.

What sizes are available for Brostallicin HCl?

Brostallicin HCl is available in the following size(s): 25 mg, 50 mg, 100 mg.

How many pack sizes does Brostallicin HCl come in?

Brostallicin HCl is available in 3 different pack sizes.

Is Brostallicin HCl in stock?

Brostallicin HCl is currently made to order / not held in immediate stock. Contact us for lead time.

Who manufactures Brostallicin HCl?

Brostallicin HCl is manufactured by Molfinity.

What is the estimated delivery time for Brostallicin HCl?

Estimated delivery time for Brostallicin HCl is approximately 10 business day(s), depending on your location.

Brostallicin HCl

Product Specifications

CAS Number

203258-38-2

Target

DNA Alkylator/Crosslinker, Others

Related Pathways

Others, DNA Damage/DNA Repair

Bioactivity

Brostallicin is a synthetic, alpha-bromoacrylic, second-generation minor groove binder (MGB), related to distamycin A, with potential antineoplastic activity. Brostallicin binds to DNA minor groove DNA, after having formed a highly reactive glutathione (GSH) -brostallicin complex in the presence of the enzyme glutathione S-transferase (GST), which is overexpressed in cancer cells; DNA replication and cell division are inhibited, resulting in tumor cell death. Compared to typical MGBs, this agent appears to bind covalently to DNA in a different manner and its activity does not depend on a functional DNA mismatch repair (MMR) mechanism. Accordingly, brostallicin may be effective against MMR-defective tumors that are refractory to various anticancer agents.