Istaroxime oxalate
Product Specifications
CAS Number
203737-94-4
Target
ATPase, Others
Related Pathways
Others, Membrane transporter/Ion channel
Bioactivity
Istaroxime, also known as PST-2744, is a positive inotropic agent that mediates its action through inhibition of sodium/potassium adenosine triphosphatase (Na+/K+ ATPase) . Na+/K+ ATPase inhibition increases intracellular sodium levels, which reverses the driving force of the sodium/calcium exchanger, inhibiting calcium extrusion and possibly facilitating calcium entry. Additionally, Istaroxime increases intracellular calcium by improving the efficacy by which intracellular calcium triggers sarcoplasmic reticulum calcium release, and by accelerating the inactivation state of L-type calcium channels, which allow for calcium influx.
Smiles
OC(=O)C(O)=O.[H][C@@]12CCC(=O)[C@@]1(C)CC[C@@]1([H])[C@@]2([H])CC(=O)[C@@]2([H])CC(CC[C@]12C)=NOCCN
Molecular Formula
C23H34N2O7
Molecular Weight
450.53
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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