BRF110
Product Specifications
CAS Number
2095489-35-1
Target
Retinoid Receptor|||NR4A|||Others
Related Pathways
Endocrinology/Hormones|||Metabolism|||Others
Bioactivity
BRF110 is a brain penetrant, potent and selective agonist of nuclear receptor-related 1 (Nurr1) :Retinoid X receptor ? (RXR?) heterodimer. BRF110 is a neuroprotective agent that prevents dopaminergic neuron demise and striatal dopaminergic denervation in vivo against PD-causing toxins. It induced dopamine biosynthesis in vivo. BRF110 chronic dosing does not induce dyskinesia in mice model.
Smiles
C(C=C)C=1C(N(C)C2=CC=C(C(O)=O)C=C2)=NC(=NC1C(F)(F)F)C3=CC=CC=C3
Molecular Formula
C22H18F3N3O2
Molecular Weight
413.39
Shipping Conditions
Cool pack
Storage Temperature
-20°C
Available Sizes
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