AMP423
Product Specifications
CAS Number
219501-57-2
Target
Others
Related Pathways
Others
Bioactivity
AMP423 is a naphthyl derivative of 2-cyanoaziridine-1-carboxamide with structural similarity to the pro-oxidant anti-tumor agent imexon. AMP423 was active in SCID mice bearing 8226/S myeloma and SU-DHL-6 B-cell lymphoma tumors, with a median tumor growth delay (T-C) of 21 days (P = 0.0002) and 5 days (P = 0.004), respectively, and a median tumor growth inhibition (T/C) of 33.3% (P = 0.03) and 82% (P = 0.01), respectively. In non-tumor-bearing mice, AMP423 was not myelosuppressive.
Smiles
N(C(=O)N1C(C#N)C1)C=2C3=C(C=CC2)C=CC=C3
Molecular Formula
C14H11N3O
Molecular Weight
237.26
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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