VU6007477
Product Specifications
CAS Number
2220141-46-6
Target
Others, P-gp
Related Pathways
Membrane transporter/Ion channel, Neuroscience, Others
Purity
0.9967
Bioactivity
VU6007477 is a novel M1 PAM. VU6007477 resulted in good rat M1 PAM potency (EC50 = 230 nM, 93% ACh max), minimal M1 agonist activity (agonist EC50 > 10 μM), good CNS penetration (rat brain/plasma Kp = 0.28, Kp, uu = 0.32; mouse Kp = 0.16, Kp, uu = 0.18), and no cholinergic adverse events (AEs, e.g., seizures) .
Smiles
C(C1=C2C(=NC(C(NC3CCOCC3)=O)=C1)N(C)C=C2)C=4C=CC(=NC4)C5=CN(C)N=C5
Molecular Formula
C24H26N6O2
Molecular Weight
430.5
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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