Gusacitinib HCl
Product Specifications
CAS Number
2228989-14-6
Target
JAK, Others, Syk
Related Pathways
JAK/STAT signaling, Chromatin/Epigenetic, Angiogenesis, Others, Tyrosine Kinase/Adaptors, Stem Cells
Bioactivity
Gusacitinib, also known as ASN-002 and EN-3351, is a potent dual inhibitor of SYK/JAK kinases. ASN002 showed strong antitumor activity in both hematological and solid tumor xenograft models. ASN002 strongly suppressed the SYK and JAK family kinase signaling pathways as measured in pLAT and pSTAT assays, respectively. When profiled in a panel of 178 cell lines, ASN002 showed strong anti-proliferative activity in many lymphoid/leukemia cell lines, including SU-DHL-6, SU-DHL-4, OCI-LY10, H929 and Pfeiffer.
Smiles
Cl.OC1CCN(CC1)c1ccc(Nc2nc(nc3cn[nH]c(=O)c23)N2CCC(CC#N)CC2)cc1
Molecular Formula
C24H29ClN8O2
Molecular Weight
497
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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