Flutamide-d7
Product Specifications
CAS Number
223134-72-3
Target
Androgen Receptor
Related Pathways
Endocrinology/Hormones
Bioactivity
Flutamide-d7 is intended for use as an internal standard for the quantification of flutamide by GC- or LC-MS. Flutamide is an androgen receptor antagonist and prodrug form of 2-hydroxy flutamide. Flutamide is converted to 2-hydroxy flutamide by the cytochrome P450 (CYP) isoform CYP1A2 in human liver microsomes. It is cytotoxic to PC3 and LNCaP prostate cancer cells with IC50 values of 98.8 and 81.8 µM, respectively. Flutamide (50 mg/kg per day) reduces tumor growth in a PC-82 mouse xenograft model. Formulations containing flutamide have been used in the treatment of prostate cancer.
Smiles
C(F)(F)(F)C1=C(N(=O)=O)C=CC(NC(C(C([2H])([2H])[2H])(C([2H])([2H])[2H])[2H])=O)=C1
Molecular Formula
C11H4D7F3N2O3
Molecular Weight
283.26
Shipping Conditions
Cool pack
Storage Temperature
-20°C
Available Sizes
Curated Selection
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