MEDS433
Product Specifications
CAS Number
2241027-61-0
Target
Others|||Dehydrogenase
Related Pathways
Others|||Metabolism
Bioactivity
MEDS433 is a dihydroorotate dehydrogenase inhibitor (IC50 1.2 nM) . MEDS433 inhibited the in vitro replication of hCoV-OC43 and hCoV-229E, as well as of SARS-CoV-2, at low nanomolar range. Notably, the anti-SARS-CoV-2 activity of MEDS433 against SARS-CoV-2 was also observed in kidney organoids generated from human embryonic stem cells.
Smiles
C(NC1=C(F)C(F)=C(C(F)=C1F)C2=CC=CC=C2)(=O)C3=C4N(NC3=O)C=CC=C4
Molecular Formula
C20H11F4N3O2
Molecular Weight
401.31
Shipping Conditions
Cool pack
Storage Temperature
-20°C
Available Sizes
Curated Selection
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