Cilofexor tromethamine
Product Specifications
CAS Number
2253764-93-9
Target
FXR, Autophagy, Others
Related Pathways
Metabolism, Autophagy, Others
Bioactivity
Cilofexor, also known as GS-9674, is a farnesoid X receptor (FXR) agonist. The nonsteroidal FXR agonist cilofexor (GS-9674) improves markers of cholestasis and liver injury in patients with PSC. In clinical study, cilofexor was well tolerated and led to significant improvements in liver biochemistries and markers of cholestasis in patients with PSC.
Smiles
NC(CO)(CO)CO.OC(=O)c1ccnc(c1)N1CC(O)(C1)c1ccc(OCc2c(onc2-c2c(Cl)cccc2Cl)C2CC2)cc1Cl
Molecular Formula
C32H33Cl3N4O8
Molecular Weight
707.99
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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