BMS-986318
Product Specifications
CAS Number
2314378-09-9
Target
FXR, Others
Related Pathways
Others, Metabolism
Bioactivity
BMS-986318 is a potent nonbile acid FXR agonist with EC50 values of 53 nM (FXR Gal4) and 350 nM (SRC-1 recruitment assays) . It has a favorable ADME profile and demonstrates effectiveness in mouse models of liver cholestasis and fibrosis caused by bile duct ligation. BMS-986318 is used in research on nonalcoholic steatohepatitis.
Smiles
ClC=1C(C=2C(C=3CC4(C3)CCN(CC4)C5=CC6=C(C=C5)N=C(C(O)=O)C=C6C(F)(F)F)=C(ON2)C7CC7)=C(Cl)C=NC1
Molecular Formula
C30H23Cl2F3N4O3
Molecular Weight
615.43
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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